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The Journal of Bone and Joint Surgery 78:106-10 (1996)
© 1996 The Journal of Bone and Joint Surgery, Inc.

Benign Giant-Cell Tumor of Bone with Metastasis to Mediastinal Lymph Nodes. A Case Report of Resection Facilitated with Use of steroids*

JONATHAN J. LEWIS, M.D., PH.D.{dagger}, JOHN H. HEALEY, M.D.{dagger}, ANDREW G. HUVOS, M.D.{dagger} and MICHAEL BURT, M.D., PH.D.{dagger}, NEW YORK, N.Y.

Investigation performed at Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York City


   Introduction
 
Benign giant-cell tumor of bone is an aggressive lesion that behaves in an unpredictable fashion. These benign tumors often recur locally and, although it is rare, may even metastasize. The frequency of metastases is approximately 2 to 3 per cent12,19. Most metastases are to the lung; metastases to other sites, including the regional lymph nodes, the scalp, and the pelvis, are extremely rare. This report describes a patient who was referred to our institution because of a local recurrence of benign giant-cell tumor that was later complicated by metastasis to the mediastinal lymph nodes.


   Case Report
 
A fifty-nine-year-old man was first seen at another institution in March 1986. He reported that he had had pain in the right wrist for five months. Radiographic evaluation revealed a large, well delineated, lucent tumor of the distal part of the radius that was consistent with a diagnosis of benign giant-cell tumor. The patient was . . . [Full Text of this Article]


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