The Journal of Bone and Joint Surgery (American). 2008;90:99-110.
doi:10.2106/JBJS.G.01546
© 2008 The Journal of Bone and Joint Surgery, Inc.
Gene Therapy Applications for Fracture-Healing
Bradley C. Carofino, MD and
Jay R. Lieberman, MD
Corresponding author: Jay R. Lieberman, MD Medical Arts and Research
Building, 263 Farmington Avenue, Farmington, CT 06030-5456
Disclosure: In support of their research for or preparation of this
work, one or more of the authors received, in any one year, outside funding or
grants in excess of $10,000 from the National Institutes of Health
Musculoskeletal Transplant Foundation. Neither they nor a member of their
immediate families received payments or other benefits or a commitment or
agreement to provide such benefits from a commercial entity. Commercial
entities (DePuy, Inc.; Amgen, Inc.; and Arthrex, Inc.) paid or directed in any
one year, or agreed to pay or direct, benefits in excess of $10,000 to a
research fund, foundation, division, center, clinical practice, or other
charitable or nonprofit organization with which one or more of the authors, or
a member of his or her immediate family, is affiliated or associated.
Biologic therapies to promote fracture-healing such as use of bone
morphogenetic proteins (BMPs) are being increasingly employed in multiple
clinical scenarios. However, it has been challenging to design therapies that
deliver sufficient quantities of protein over a sustained time period. A
potential solution is the application of gene therapy that transfers genetic
information to host cells at the fracture site, resulting in the continuous
and localized production of the desired proteins. This approach has
demonstrated tremendous potential in preclinical animal models of
fracture-healing. This article will review the current state of gene therapy
approaches to fracture-healing with an emphasis on potential clinical
applications.

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