The Journal of Bone and Joint Surgery (American). 2008;90:99-110.
doi:10.2106/JBJS.G.01546
© 2008 The Journal of Bone and Joint Surgery, Inc.
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Gene Therapy Applications for Fracture-Healing

Bradley C. Carofino, MD and Jay R. Lieberman, MD

Corresponding author:
Jay R. Lieberman, MD
Medical Arts and Research Building, 263 Farmington Avenue, Farmington, CT 06030-5456

Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the National Institutes of Health Musculoskeletal Transplant Foundation. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. Commercial entities (DePuy, Inc.; Amgen, Inc.; and Arthrex, Inc.) paid or directed in any one year, or agreed to pay or direct, benefits in excess of $10,000 to a research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which one or more of the authors, or a member of his or her immediate family, is affiliated or associated.

Biologic therapies to promote fracture-healing such as use of bone morphogenetic proteins (BMPs) are being increasingly employed in multiple clinical scenarios. However, it has been challenging to design therapies that deliver sufficient quantities of protein over a sustained time period. A potential solution is the application of gene therapy that transfers genetic information to host cells at the fracture site, resulting in the continuous and localized production of the desired proteins. This approach has demonstrated tremendous potential in preclinical animal models of fracture-healing. This article will review the current state of gene therapy approaches to fracture-healing with an emphasis on potential clinical applications.


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