The Journal of Bone and Joint Surgery (American). 2008;90:99-110.
doi:10.2106/JBJS.G.01546
© 2008 The Journal of Bone and Joint Surgery, Inc.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JBJS
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Google Scholar
Right arrow Articles by Carofino, B. C.
Right arrow Articles by Lieberman, J. R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carofino, B. C.
Right arrow Articles by Lieberman, J. R.
Related Collections
Right arrow Basic Science
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?

Gene Therapy Applications for Fracture-Healing

Bradley C. Carofino, MD and Jay R. Lieberman, MD

Corresponding author:
Jay R. Lieberman, MD
Medical Arts and Research Building, 263 Farmington Avenue, Farmington, CT 06030-5456

Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the National Institutes of Health Musculoskeletal Transplant Foundation. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. Commercial entities (DePuy, Inc.; Amgen, Inc.; and Arthrex, Inc.) paid or directed in any one year, or agreed to pay or direct, benefits in excess of $10,000 to a research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which one or more of the authors, or a member of his or her immediate family, is affiliated or associated.

Biologic therapies to promote fracture-healing such as use of bone morphogenetic proteins (BMPs) are being increasingly employed in multiple clinical scenarios. However, it has been challenging to design therapies that deliver sufficient quantities of protein over a sustained time period. A potential solution is the application of gene therapy that transfers genetic information to host cells at the fracture site, resulting in the continuous and localized production of the desired proteins. This approach has demonstrated tremendous potential in preclinical animal models of fracture-healing. This article will review the current state of gene therapy approaches to fracture-healing with an emphasis on potential clinical applications.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?

Related articles in JBJS:

The Effect of Regional Gene Therapy with Bone Morphogenetic Protein-2-Producing Bone-Marrow Cells on the Repair of Segmental Femoral Defects in Rats
JAY R. LIEBERMAN, AARON DALUISKI, SHARON STEVENSON, LA JOLLA, LILY WU, PAULA McALLISTER, YU PO LEE, J. MICHAEL KABO, GERALD A.M. FINERMAN, ARNOLD J. BERK, and OWEN N. WITTE
JBJS 1999 81: 905-17. [Abstract] [Full Text]