The Journal of Bone and Joint Surgery (American). 2008;90:92-98.
doi:10.2106/JBJS.G.01192
© 2008 The Journal of Bone and Joint Surgery, Inc.
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Nonunions and the Potential of Stem Cells in Fracture-Healing

Susan S. Tseng, MD, Mark A. Lee, MD and A. Hari Reddi, PhD

Corresponding author:
A. Hari Reddi, PhD
Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, 4635 Second Avenue, Research Building 1, Room 2000, Sacramento, CA 95817.
E-mail address: ahreddi{at}ucdavis.edu

Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the Lawrence J. Ellison Endowment and less than $10,000 from Denny and Jeanine Dickinson in support of orthopaedic surgery resident research. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

Recent progress in human embryonic and adult stem cell research is a cause for much enthusiasm in bone and joint surgery. Stem cells have therapeutic potential in the realm of orthopaedic surgery because of their capacity to self-renew and differentiate into various types of mature cells and tissues, including bone. Because nonunions remain a clinically important problem, there is interest in the use of cell-based strategies to augment fracture repair. Such strategies are being investigated with variations in the model systems, sources of stem cells, and methods for the application and enhancement of osseous healing, including genetic modifications and tissue-engineering. This review highlights the recent progress in the utilization of stem cells and cell-based gene therapy in promoting fracture-healing and its potential utility in the clinical setting.


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