The Journal of Bone and Joint Surgery (American). 2008;90:79-84.
doi:10.2106/JBJS.G.01585
© 2008 The Journal of Bone and Joint Surgery, Inc.
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Selection and Development of Preclinical Models in Fracture-Healing Research

Padhraig F. O'Loughlin, MD, Simon Morr, BA, Ljiljana Bogunovic, BA, Abraham D. Kim, BA, Brian Park, BS and Joseph M. Lane, MD

Corresponding author:
Joseph M. Lane, MD
The Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021.
E-mail address: lanej{at}hss.edu

Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

Animal fracture models have been extensively applied to preclinical research as a platform to identify and characterize normal and abnormal physiological processes and to develop specific maneuvers that alter the biology and biomechanics being examined. The choice of animal model employed in a study bears a direct relationship to the specific intervention being analyzed. The animal models employed should be described clearly, control-group data should be established, and reproducibility should be defined from experiment to experiment and from institution to institution so that quantitative and qualitative outcomes can be reliably compared and contrasted to other related studies.


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