The Journal of Bone and Joint Surgery (American). 2008;90:128-131.
doi:10.2106/JBJS.G.01520
© 2008 The Journal of Bone and Joint Surgery, Inc.
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Nanofibers and Nanoparticles for Orthopaedic Surgery Applications

Lakshmi S. Nair, MPhil, PhD and Cato T. Laurencin, MD, PhD

Corresponding author:
Lakshmi S. Nair, MPhil, PhD
Department of Orthopaedic Surgery, University of Virginia, 415 Lane Road, Box 800759, Charlottesville, VA 22908.
E mail address: nair{at}virginia.edu

Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

The ability of nanostructures to elicit altered cell behaviors, including cell adhesion, proliferation, orientation, motility, integrin expression, cytoskeletal organization, and modulation of intracellular signaling, has raised heightened interest in these materials for various biomedical applications, including orthopaedic repair and regeneration. Studies have demonstrated that nanofibrous structures can favorably modulate osteoblast, osteoclast, and fibroblast activities toward implant and/or scaffold materials. Nanomaterials based on silver nanoparticles have received significant attention. Apart from their unique wound-healing ability, silver nanoparticles also exhibit high antibacterial properties, making them potential candidates for use in the development of infection-resistant biomaterials.


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