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Overlapping Systematic Reviews of Anterior Cruciate Ligament Reconstruction Comparing Hamstring Autograft with Bone-Patellar Tendon-Bone Autograft: Why Are They Different?

¹ Onze Lieve Vrouwe Gasthuis, Department of Orthopedic Surgery, Post-bus 95500, 1090 HM Amsterdam, The Netherlands. E-mail address: Poolman{at}trauma.nl
² Hamilton General Hospital, McMaster University, 7 North, Room 727, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada

Investigation performed at the Division of Orthopaedic Surgery, Orthopaedic Research Unit, McMaster University, Ontario, Canada

Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from a Stichting Wetenschappelijk Onderzoek Orthopaedische Chirurgie Fellowship, Biomet Netherlands, Anna Fonds, Zimmer Netherlands, MSD The Netherlands, a Nederlandse Vereniging voor Orthopedische Traumatologie Fellowship, and a Canada Research Chair from the Canadian Institutes of Health Research. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

Methods: We performed a search of MEDLINE, the Cochrane Database of Systematic Reviews, and EMBASE to identify systematic reviews in which bone-patellar tendon-bone graft was compared with hamstring tendon autograft for reconstruction of the anterior cruciate ligament. We evaluated cross-citations among the overlapping reviews and the authors' rationale for repeating the review. The quality of reporting was assessed with the Quality of Reporting of Meta-analyses (QUOROM) statement, and the internal validity was assessed with the Oxman and Guyatt index for methodological quality by at least two assessors. Assessor agreement was evaluated with intraclass correlation coefficients. We evaluated the sensitivity analysis that had been performed in the reviews.

Results: We identified eleven overlapping systematic reviews. Three reviews favored the patellar tendon graft for stability, and one favored the hamstring graft. Six reviews favored the hamstring graft to prevent anterior knee pain, and the rest were inconclusive. Only six reviews cited previously published systematic reviews on the same topic, and only two of these reviews cited all available systematic reviews that were available at that time. The quality of reporting ranged from 5 to 18 (median, 12; maximum score, 18). The internal validity ranged from 1 to 7 (median, 2; maximum score, 7). Reviewers reached almost perfect agreement (intraclass correlation coefficients, 0.83 and 0.94). Formal sensitivity analysis was utilized infrequently. The highest-quality review favored hamstring grafts to prevent anterior knee pain and showed weak evidence that bone-patellar tendon-bone grafts yielded better stability.

Conclusions: When overlapping or discordant systematic reviews are encountered, each review must be appraised on the basis of its methodological quality before it can be used to guide clinical decision-making or policy making. The currently available best evidence, derived from a methodologically sound meta-analysis, suggests that hamstring tendon autografts are superior for preventing anterior knee pain, and there is limited evidence that bone-patellar tendon-bone autografts provide better stability.

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				T. E. Foster, B. L. Wolfe, S. Ryan, L. Silvestri, and E. K. Kaye Does the Graft Source Really Matter in the Outcome of Patients Undergoing Anterior Cruciate Ligament Reconstruction?: An Evaluation of Autograft Versus Allograft Reconstruction Results: A Systematic Review Am. J. Sports Med., January 1, 2010; 38(1): 189 - 199. [Abstract] [Full Text] [PDF]

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