The Journal of Bone and Joint Surgery (American). 2007;89:418-426.
doi:10.2106/JBJS.F.00362
© 2007 The Journal of Bone and Joint Surgery, Inc.
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Current Concepts Review

Institutional Review Board Approval: Why It Matters

Javad Parvizi, MD, FRCS1, T. David Tarity, BS1, Kyle Conner, MA2 and J. Bruce Smith, MD2

1 Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA 19107. E-mail address for J. Parvizi: parvj{at}aol.com
2 Thomas Jefferson University, Office of Human Research, Division of Human Subjects Protection, Philadelphia, PA 19107

Investigation performed at Thomas Jefferson University, Philadelphia, Pennsylvania

Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

The modern institutional review boards originated in the 1970s. They exist to protect human subjects participating in research from potential harm.

The Belmont Report provided the ethical principles (respect for persons, beneficence, and justice) that should be observed while conducting research on human subjects.

Compliance with the ethical principles of the Belmont Report is a first step in successful submissions to an institutional review board.

Regulations regarding conflict of interest represent an attempt to ensure that research is not biased by financial or other interest and to maintain public trust.


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