The Journal of Bone and Joint Surgery (American). 2005;87:1848-1864.
doi:10.2106/JBJS.D.02942
© 2005 The Journal of Bone and Joint Surgery, Inc.
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow CME: Take the activities for this article:
 CME 3: July, August, September 2005
Oncology Test 4: Spring 2006 (publication date May 15, 2006; expiration dat...
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DiCaprio, M. R.
Right arrow Articles by Enneking, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DiCaprio, M. R.
Right arrow Articles by Enneking, W. F.
Related Collections
Right arrow Current Concepts Review
Right arrow Oncology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Facebook   Add to Technorati   Add to Twitter  
What's this?

Current Concepts Review

Fibrous Dysplasia

Pathophysiology, Evaluation, and Treatment

Matthew R. DiCaprio, MD1 and William F. Enneking, MD2

1 Schenectady Regional Orthopaedic Associates, 530 Liberty Street, Schenectady, NY 12305. E-mail address: mdicaprio{at}nycap.rr.com
2 Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, 3450 Hull Road, Gainesville, FL 32608

Investigation performed at the Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville, Florida

The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

Fibrous dysplasia is a common benign skeletal lesion that may involve one bone (monostotic) or multiple bones (polyostotic) and occurs throughout the skeleton with a predilection for the long bones, ribs, and craniofacial bones.

The etiology of fibrous dysplasia has been linked to an activating mutation in the gene that encodes the {alpha} subunit of stimulatory G protein (Gs{alpha}) located at 20q13.2-13.3.

Most lesions are monostotic, asymptomatic, and identified incidentally and can be treated with clinical observation and patient education.

Bisphosphonate therapy may help to improve function, decrease pain, and lower fracture risk in appropriately selected patients with fibrous dysplasia.

Surgery is indicated for confirmatory biopsy, correction of deformity, prevention of pathologic fracture, and/or eradication of symptomatic lesions. The use of cortical grafts is preferred over cancellous grafts or bone-graft substitutes because of the superior physical qualities of remodeled cortical bone.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Facebook Facebook   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Br. J. Radiol.Home page
C REIS, E M GENDEN, J B BEDERSON, and P M SOM
A rare spontaneous osteosarcoma of the calvarium in a patient with long-standing fibrous dysplasia: CT and MR findings
Br. J. Radiol., February 1, 2008; 81(962): e31 - e34.
[Abstract] [Full Text] [PDF]