The Journal of Bone and Joint Surgery (American). 2005;87:1609-1618.
doi:10.2106/JBJS.D.03032
© 2005 The Journal of Bone and Joint Surgery, Inc.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the exams for this article:
 CME 3: July, August, September 2005
Adult Hip Reconstruction Test 15: Fall 2005
Adult Knee Reconstruction Test 10: Fall 2005
Spine Test 8: Fall 2005
Right arrow Letters to the Editor: Submit a response
Right arrow Letters to the Editor: View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morris, C. D.
Right arrow Articles by Einhorn, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morris, C. D.
Right arrow Articles by Einhorn, T. A.
Related Collections
Right arrow Basic Science
Right arrow Current Concepts Review
Right arrow Spine
Right arrow Adult Hip
Right arrow Adult Knee
Right arrow Pediatrics
Right arrow Oncology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?

Current Concepts Review

Bisphosphonates in Orthopaedic Surgery

Carol D. Morris, MD, MS1 and Thomas A. Einhorn, MD2

1 Orthopaedic Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Suite A-342, New York, NY 10021. E-mail address: morrisc{at}mskcc.org
2 Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Boston, MA 02116

Investigation performed at Memorial Sloan-Kettering Cancer Center, New York, NY, and Boston University Medical Center, Boston, Massachusetts

Bisphosphonates are the most clinically important class of antiresorptive agents available to treat diseases characterized by osteoclast-mediated bone resorption.

Currently, seven bisphosphonates have the approval of the United States Food and Drug Administration.

The most common adult diseases treated with bisphosphonates include osteoporosis, Paget disease, and metastatic bone disease.

The treatment of pediatric disorders such as osteogenesis imperfecta and fibrous dysplasia with bisphosphonates has gained momentum, and initial investigations have demonstrated an acceptable safety profile.

Currently, there is a lack of long-term follow-up data, which will be necessary for the development of responsible guidelines for therapy.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Am Acad Orthop SurgHome page
G. Burnei, C. Vlad, I. Georgescu, T. S. Gavriliu, and D. Dan
Osteogenesis Imperfecta: Diagnosis and Treatment
J. Am. Acad. Ortho. Surg., June 1, 2008; 16(6): 356 - 366.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
F. A. Matsen III, J. Clinton, J. Lynch, A. Bertelsen, and M. L. Richardson
Glenoid Component Failure in Total Shoulder Arthroplasty
J. Bone Joint Surg. Am., April 1, 2008; 90(4): 885 - 896.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
S. R. Majumdar, L. A. Beaupre, C. H. Harley, D. A. Hanley, D. A. Lier, A. G. Juby, W. P. Maksymowych, J. G. Cinats, N. R. Bell, and D. W. Morrish
Use of a Case Manager to Improve Osteoporosis Treatment After Hip Fracture: Results of a Randomized Controlled Trial
Arch Intern Med, October 22, 2007; 167(19): 2110 - 2115.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
M. Ramachandran, K. Ward, R. R. Brown, C. F. Munns, C. T. Cowell, and D. G. Little
Intravenous Bisphosphonate Therapy for Traumatic Osteonecrosis of the Femoral Head in Adolescents
J. Bone Joint Surg. Am., August 1, 2007; 89(8): 1727 - 1734.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
A. Moroni, C. Faldini, A. Hoang-Kim, F. Pegreffi, and S. Giannini
Alendronate Improves Screw Fixation in Osteoporotic Bone
J. Bone Joint Surg. Am., January 1, 2007; 89(1): 96 - 101.
[Abstract] [Full Text] [PDF]

Home page
 IBMS BoneKEyHome page
M. J. Somerman and L. K. McCauley
Bisphosphonates: Sacrificing the Jaw to Save the Skeleton?
IBMS BoneKEy, September 1, 2006; 3(9): 12 - 18.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
S. D. Boden, T. A. Einhorn, T. S. Morgan, L. L. Tosi, and J. N. Weinstein
An AOA Critical Issue. The Future of the Orthopaedic Surgeon-Proceduralist or Keeper of the Musculoskeletal System?
J. Bone Joint Surg. Am., December 1, 2005; 87(12): 2812 - 2821.
[Full Text] [PDF]

Letters to the Editor:

Read all Letters to the Editor

re: FDA approved Bisphosphonates
John J Carey, et al.
JBJS Online, 9 Aug 2005 [Full text]