This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheville, A.
Right arrow Articles by Narcessian, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheville, A.
Right arrow Articles by Narcessian, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Facebook   Add to Technorati   Add to Twitter  
What's this?
The Journal of Bone and Joint Surgery 83:572 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

A Randomized Trial of Controlled-Release Oxycodone During Inpatient Rehabilitation Following Unilateral Total Knee Arthroplasty

Andrea Cheville, MD, Alice Chen, MD, Gerry Oster, PhD, Lisa McGarry, MPH and Elizabeth Narcessian, MD

Investigation performed at Kessler Institute for Rehabilitation, East Orange and West Orange, New Jersey
No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.
Andrea Cheville, MD Department of Rehabilitation Medicine, University of Pennsylvania Health System, 3400 Spruce Street, 5 West Gates, Philadelphia, PA 19104. E-mail address: cheville{at}mail.med.upenn.edu
Alice Chen, MD Beth Israel Medical Center, 170 East End Avenue, New York, NY 10128
Gerry Oster, PhD Lisa McGarry, MPH Policy Analysis, Incorporated, 4 Davis Court, Brookline, MA 02445
Elizabeth Narcessian, MD Deceased

Background:

Reliance on "as-needed" analgesia following total knee arthroplasty may lead to inadequate control of pain and delayed recovery of function. Preemptive use of controlled-release opioids may improve pain control, accelerate recovery, and reduce the need for inpatient rehabilitative services. This study was designed to determine whether controlled-release opioids enhance post-arthroplasty pain control and facilitate functional recovery during rehabilitation.

Methods:

Fifty-nine patients admitted for inpatient rehabilitation following unilateral total knee arthroplasty were randomized to receive OxyContin (controlled-release oxycodone) (twenty-nine patients) or a placebo (thirty patients) every twelve hours. Both groups could receive on-request, immediate-release oxycodone (5 mg every four hours). The dose of study medication was increased on the basis of the frequency of requests for immediate-release oxycodone. Measures of interest included pain ratings as determined with a visual-analog scale, changes in the range of motion of the knee and quadriceps strength, and improvements in selected Functional Independence Measure scores during the first eight physical therapy sessions. The duration of the hospital stay for rehabilitation also was compared between the two groups.

Results:

Baseline demographic, clinical, and functional characteristics were similar between the OxyContin and placebo groups. Compared with the placebo group, the patients who received OxyContin reported significantly less pain as well as significantly greater range of motion of the knee (passive motion, p = 0.036; active motion, p < 0.001) and quadriceps strength (p = 0.001) by the eighth physical therapy session. The patients who received OxyContin also were discharged from the rehabilitation hospital at an average of 2.3 days earlier than the patients in the placebo group (p = 0.013).

Conclusions:

Preemptive use of controlled-release oxycodone during rehabilitation following total knee arthroplasty leads to improved pain control, more rapid functional recovery, and a reduced need for inpatient rehabilitative services.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Facebook Facebook   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J Am Acad Orthop SurgHome page
A. M. Levine and R. K. Burdick
Controlled-Release Oxycodone
J. Am. Acad. Ortho. Surg., January 1, 2005; 13(1): 1 - 4.
[Full Text] [PDF]

Home page
 JBJSHome page
M. J. Botte, K. A. Ezzet, L. L. Pacelli, M. J. Guzman, R. S. Meyer, M. J. Meunier, D. D. D'Lima, and C. W. Colwell
What's New in Orthopaedic Rehabilitation
J. Bone Joint Surg. Am., December 9, 2002; 84(12): 2312 - 2320.
[Full Text] [PDF]