The Journal of Bone and Joint Surgery, Vol 76, Issue 4 482-488, Copyright © 1994 by Journal of Bone and Joint Surgery, Inc
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy
GE Rivard, M Girard, R Belanger, M Jutras, JP Guay and D Marton
Department of Pediatrics, Hopital Sainte-Justine, Montreal, Quebec, Canada.
Between 1977 and 1992, we performed ninety-two synoviortheses (destruction
of synovial tissue by intra-articular injection of a radioactive agent) on
forty-eight patients who had a severe congenital disorder of hemostasis and
chronic hemophilic synovitis that was resistant to conventional treatment.
Colloidal 32P chromic phosphate was injected intra-articularly: 1.0
millicurie for knees and 0.5 millicurie for other joints. The duration of
follow-up ranged from one to fifteen years. The frequency and importance of
bleeding decreased in most of the patients. The range of motion of half of
the joints remained stable or improved and that of the other half continued
to decrease. Radiographic scores worsened progressively despite the
decreased frequency of hemarthrosis. In most patients, the extra-articular
leakage of the radioactive agent was slight. Chromosome breakages were
observed almost exclusively in patients who were seropositive for human
immunodeficiency virus and in whom the CD4-lymphocyte count was decreased
from normal. The patients' level of satisfaction with the results was high.
CiteULike 
Connotea 
Del.icio.us 
Technorati What's this?
