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The Journal of Bone and Joint Surgery, Vol 76, Issue 10 1500-1506, Copyright © 1994 by Journal of Bone and Joint Surgery, Inc
Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model
KL Garvin, JA Miyano, D Robinson, D Giger, J Novak and S Radio
University of Nebraska Medical Center, Omaha 68198-1080.
Osteomyelitis with Staphylococcus aureus was established in the tibiae of
twenty-six adult mongrel dogs. After confirmation of infection at four
weeks, all animals had operative debridement and were then divided into
three treatment groups. Group 1 (eight animals [sixteen tibiae]) was
treated with parenteral administration of gentamicin (three milligrams per
kilogram of body weight per day) every eight hours for four weeks. Group 2
(nine animals [nine tibiae]) was treated with a polymethylmethacrylate
implant containing 100 milligrams of gentamicin that was placed in the
tibia for six weeks. Group 3 (nine animals [nine tibiae]) was treated with
a polylactide/polyglycolide implant containing 100 milligrams of gentamicin
that was placed in the tibia for six weeks. All animals were killed at the
end of treatment. At that time, specimens of tissue were obtained for
quantitative culture as well as for antibiotic immunoassay. In the groups
that had been treated with an implant, serum was obtained for the
measurement of serum drug levels after debridement; after the implantation;
four, seven, and twenty-one days postoperatively; and immediately before
the animals were killed. The infection was eradicated in ten of the sixteen
tibiae in Group 1, in eight of the nine tibiae in Group 2, and in all nine
tibiae in Group 3.(ABSTRACT TRUNCATED AT 250 WORDS)
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