The Journal of Bone and Joint Surgery, Vol 75, Issue 11 1663-1673, Copyright © 1993 by Journal of Bone and Joint Surgery, Inc
Fractures in large-segment allografts
RC Thompson, EA Pickvance and D Garry
Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55455.
Sixteen of thirty-five large-segment allografts that had been implanted
after resection for neoplastic conditions, and had been followed for a
minimum of thirty-six months, were found to have fractured at a mean of
twenty-six months after the implantation. Thirteen of the fractures were
treated operatively, and we found a lack of vascularization and soft-tissue
attachments to the graft at the fracture site. For seven fractured grafts,
there were radiographic and clinical signs of union with the host bone.
Eight of the sixteen grafts that had fractured were salvaged with one or
more autogenous bone grafts, and two healed spontaneously. Thus,
twenty-nine of the thirty-five grafting procedures were considered to have
been successful in that the initial objective--provision of a functional
segment for skeletal replacement--had been achieved. Multivariate analysis
revealed a significant correlation for fracture in patients who were
receiving chemotherapy when internal fixation of the graft had included
devices that penetrated the cortices of the graft (p < 0.05).
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