The Journal of Bone and Joint Surgery, Vol 75, Issue 10 1457-1465, Copyright © 1993 by Journal of Bone and Joint Surgery, Inc
Ewing sarcoma of the pelvis. Clinicopathological features and treatment
FJ Frassica, DA Frassica, DJ Pritchard, PJ Schomberg, LE Wold and FH Sim
Department of Orthopedics, Mayo Clinic, Rochester, Minnesota.
The results of treatment in twenty-seven patients who had a Ewing sarcoma
of the pelvis were reviewed. Six patients had had metastatic disease at the
time of the diagnosis. The three-year actuarial survival of these patients
was 17 per cent (95 per cent confidence interval, 8 to 52 per cent). Of the
twenty-one remaining patients, thirteen had received chemotherapy and
radiation therapy to the primary lesion and eight had had chemotherapy and
operative resection, with or without radiation therapy. The actuarial
five-year over-all survival was 25 per cent (95 per cent confidence
interval, 6 to 51 per cent) in the group that had had radiation without a
resection and 75 per cent (95 per cent confidence interval, 31 to 93 per
cent) in the group that had had a resection (p < 0.005, log-rank
method). The actuarial over-all five-year survival was 45 per cent (23 to
65 per cent) for all patients who had had localized disease when first
seen. Actuarial local failure analysis (the censoring of patients who died
without evidence of local failure before the two-year follow-up
examination) revealed a rate of local failure of 44 per cent (14 to 79 per
cent) in the group that had been treated with chemotherapy and radiation
alone compared with 13 per cent (0 to 53 per cent) in the patients who had
had a resection, but this difference was not significant (p > 0.25,
log-rank method).(ABSTRACT TRUNCATED AT 250 WORDS)
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