The Journal of Bone and Joint Surgery, Vol 75, Issue 1 53-60, Copyright © 1993 by Journal of Bone and Joint Surgery, Inc
Bone changes associated with intraosseous hypertension in the caprine tibia
RD Welch, CE Johnston, MJ Waldron and B Poteet
Texas Veterinary Medical Center, College Station.
We investigated the effects of increased intraosseous pressure on new-bone
formation in the proximal metaphysis of the caprine tibia. Intraosseous
hypertension was produced by obstruction of venous outflow by ligation of
the popliteal vein draining the proximal aspect of the tibia and occlusion
of the medullary space with bone cement (groups 1 and 2). After the
obstruction of venous outflow (day 0), the intraosseous pressure measured
at the proximal tibial metaphysis increased significantly from a mean of
15.5 millimeters of mercury before the obstruction to a mean of 28.7
millimeters of mercury in groups 1 and 2. In group 1, obstruction of venous
outflow was combined with intraosseous infusion of autogenous whole blood
under pressure to maintain the intraosseous pressure between thirty and
forty-five millimeters of mercury during days 0 through 5. The time for
venous drainage was still prolonged and intraosseous pressures were still
increased on days 5 and 10 (means, 26.8 and 26.2 millimeters of mercury,
respectively) in groups 1 and 2. The intraosseous hypertension produced in
group 1 was associated with a significant increase in periosteal (138 per
cent), endocortical (369 per cent), and cancellous new-bone formation (889
per cent) at the tibial metaphysis compared with control values. Osseous
necrosis within the metaphysis was not observed.
CiteULike 
Connotea 
Del.icio.us 
Technorati What's this?
