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The Journal of Bone and Joint Surgery, Vol 73, Issue 4 513-517, Copyright © 1991 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Bone scans in the diagnosis of bone crisis in patients who have Gaucher disease

K Katz, S Mechlis-Frish, IJ Cohen, G Horev, R Zaizov and E Lubin
Department of Orthopedic Surgery, Beilinson Medical Center, Petah Tiqva, Israel.

Of thirty-four occurrences of bone pain in seventeen children and young adults who had type-I Gaucher disease, twenty-five were finally diagnosed as bone crises. On the basis of a bone scan with technetium-99m methylene diphosphonate, a correct diagnosis of bone crisis was made for twenty-three occurrences, with a sensitivity of 0.92. At the onset of a crisis, the bone scan typically showed decreased uptake of radionuclide at the involved site. After six weeks, a repeat bone scan of the long bones showed a ring of increased uptake surrounding an area of decreased uptake. At six months, the appearance of the bones on the radionuclide scan was normal.
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