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The Journal of Bone and Joint Surgery, Vol 73, Issue 10 1532-1536, Copyright © 1991 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

X-chromosome inactivation in patients who have pigmented villonodular synovitis

RJ Sakkers, D de Jong and RO van der Heul
University Hospital Leiden, The Netherlands.

We performed a histological examination and DNA analysis on samples of tissue from a forty-seven-year-old woman who had a clinical diagnosis of pigmented villonodular synovitis. The histological examination confirmed the diagnosis. The evaluation of the samples of tissue with preferential X-chromosome inactivation analysis (a molecular biological method for the study of clonality in tumors) showed that the lesion was polyclonal in origin. We concluded, therefore, that pigmented villonodular synovitis is more likely to be a reactive process than a true neoplasm.
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