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The Journal of Bone and Joint Surgery, Vol 73, Issue 1 124-128, Copyright © 1991 by Journal of Bone and Joint Surgery, Inc
Familial predisposition for herniation of a lumbar disc in patients who are less than twenty-one years old
GP Varlotta, MD Brown, JL Kelsey and AL Golden
Department of Orthopaedics and Rehabilitation, University of Miami School of Medicine, Florida 33101.
The parents of sixty-three patients who were less than twenty-one years old
and who had operatively confirmed herniation of a lumbar disc were
interviewed regarding a history of sever back pain, sciatica, and herniated
disc, to determine whether aggregation of herniation of a lumbar disc
occurs in families of patients in this young age-group. The parents of
sixty-three additional patients who had a non-spinal orthopaedic diagnosis
(control group) were matched for age and sex with the study group and were
given the same interview. Of the patients who had herniation of a lumbar
disc and were less than twenty-one years old, 32 per cent had a positive
family history for that lesion compared with 7 per cent of the control
group. The relative risk of development of herniation of a lumbar disc
before the age of twenty-one years is estimated to be approximately five
times greater in patients who have a positive family history. The results
indicate a familial basis for herniation of a lumbar disc in patients who
are less than twenty-one years old.
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