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The Journal of Bone and Joint Surgery, Vol 71, Issue 5 684-691, Copyright © 1989 by Journal of Bone and Joint Surgery, Inc
Development of an osteogenic bone-marrow preparation
J Connolly, R Guse, L Lippiello and R Dehne
Creighton-Nebraska Universities Health Foundation Program in Orthopaedics, Omaha.
The osteogenic effect of bone marrow was tested in rabbits, using chambers
that had been implanted in the peritoneal cavity (ectopic site) and in a
delayed-union model (orthotopic site). Osteogenesis was accelerated in both
sites after concentration of marrow elements by centrifugation, but not
after unit gravity sedimentation. Chambers that were implanted with marrow
that had been processed by simple and isopyknic centrifugation demonstrated
a more pronounced increase in deposition of calcium compared with
whole-marrow implants of equal volume (101 compared with 193 per cent).
Orthotopic grafting of a rabbit delayed-union model with whole marrow and
marrow that had been processed with simple centrifugation significantly
increased osteogenesis, as measured biomechanically and biochemically.
Significantly improved healing was evident radiographically at five weeks
after grafting with bone marrow that had been concentrated by simple
centrifugation.
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