The Journal of Bone and Joint Surgery, Vol 69, Issue 7 984-992, Copyright © 1987 by Journal of Bone and Joint Surgery, Inc
Bridging large defects in bone by demineralized bone matrix in the form of a powder. A radiographic, histological, and radioisotope-uptake study in rats
R Gepstein, RE Weiss and T Hallel
Orthopaedic Department of Meir General Hospital, Kfar Saba, Israel.
Demineralized bone powder was used as an osteoinductive substance to bridge
very large defects (more than 50 per cent of the total length of the bone)
in one radius of each of thirty-three rats. An identical defect was
produced in the contralateral radius of each animal for use as a control.
The defect on the control side was left unbridged or was bridged by large
chips of autologous bone or an autologous inlay graft. All rats showed
formation of new bone throughout the length of the radial defect only on
the side in which the demineralized bone powder had been implanted. The
control side, in which an autologous graft in the form of chips or inlay
had been implanted, showed resorption of the graft. The maximum rate of
formation of bone occurred fifteen to twenty-one days after implantation of
the demineralized bone powder. At thirty-five days, the experimental defect
was fully bridged, forming solid bone, in 71 per cent of the rats, and the
remaining 29 per cent showed bridging of 95.8 per cent of the length of the
defect, with union on one side. Analysis of the sequential radiographs,
technetium-99m scans, and histological findings showed that the formation
of bone and bridging of the defect were superior on the side in which the
demineralized bone powder had been implanted compared with the side in
which pieces of autologous bone or an autologous inlay graft had been
used.(ABSTRACT TRUNCATED AT 250 WORDS)
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