The Journal of Bone and Joint Surgery, Vol 69, Issue 4 583-595, Copyright © 1987 by Journal of Bone and Joint Surgery, Inc
Tissue-typing in human massive allografts of frozen bone
DL Muscolo, E Caletti, F Schajowicz, ES Araujo and A Makino
The cases of twenty-six patients who received a massive allotransplant of
frozen bone, with a known degree of histocompatibility between the donor
and the recipient, were studied. Twenty-two patients were followed for more
than two years (range, twenty-four to ninety-two months). Twenty-three
biopsies were performed in sixteen patients from nine to seventy-eight
months after transplantation. No clear relationship could be established
between the degree of histocompatibility of the donor and the recipient and
the incorporation of the graft, probably in part due to the number of
variables involved and the polymorphism of the HLA system. However, no
early massive resorption of the transplant was seen in this series, in
which, by the design of the protocol, no recipients had pre-existing
circulating antibodies to the antigens of the donor. Two allografts showed
infiltration by round cells and vascular lesions in the absence of
infection, which is suggestive of an immune response against antigens from
the donor. Both matched poorly with the donor for HLA antigens. The
individual who had the strongest reaction was the only recipient in the
series who had a massive failure of the transplant.
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