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The Journal of Bone and Joint Surgery, Vol 68, Issue 7 1073-1079, Copyright © 1986 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients

MG Rock, FH Sim, KK Unni, GA Witrak, FJ Frassica, MF Schray, JW Beabout and DC Dahlin

Twenty-six patients who had a malignant giant-cell tumor of bone--a sarcoma either juxtaposed to a zone of typical benign giant-cell tumor or occurring at the site of a previously documented benign giant-cell tumor--have been seen at the Mayo Clinic. Of the twenty-six tumors, nineteen were secondary to a previous attempt at local control of a benign giant-cell tumor. All but one of these nineteen patients with a secondary tumor had received therapeutic irradiation four to thirty-nine years earlier. The nature and duration of the symptoms and the sites of predilection of the malignant giant-cell tumors were the same as for benign giant-cell tumor. Fibrosarcoma occurred three times as frequently as osteosarcoma. The best results of treatment of the secondary sarcoma were obtained with early ablation.
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