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The Journal of Bone and Joint Surgery, Vol 68, Issue 6 802-808, Copyright © 1986 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Evaluation of Gaucher disease using magnetic resonance imaging

DI Rosenthal, JA Scott, J Barranger, HJ Mankin, S Saini, TJ Brady, LK Osier and S Doppelt

Magnetic resonance imaging was used to study the skeletal involvement in a series of twenty-four patients with Gaucher disease. Many sites in the marrow of these patients were characterized by an abnormally low signal intensity that reflected shortened T1 and markedly shortened T2 values in the replaced marrow. The abnormality was non-homogeneous in distribution. In the lower extremity, the proximal (femoral) areas were more frequently affected than the distal (tibial) sites. The epiphyses were generally spared unless the involvement of bone was extensive. Lack of epiphyseal involvement on the magnetic resonance images generally precluded any suspicion of osteonecrosis. The extent of involvement, as suggested by the magnetic resonance data, appeared to correlate well with the occurrence of musculoskeletal complications. Magnetic resonance imaging is more sensitive than computerized tomography in demonstrating the extent of abnormalities in patients with Gaucher disease, and it may have prognostic value.
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