|
The Journal of Bone and Joint Surgery, Vol 67, Issue 6 890-900, Copyright © 1985 by Journal of Bone and Joint Surgery, Inc
Giant-cell tumor of bone with pulmonary metastases
F Bertoni, D Present and WF Enneking
We reviewed the cases of seven patients with histologically benign primary
giant-cell tumor of bone and histologically proved metastases to the lung.
All seven had a Stage-3, aggressive, benign lesion with interruption of the
cortex and soft-tissue extension. The main histological features of the
primary lesion were identical to those of the pulmonary metastases. In only
one of the seven patients were the metastases detected simultaneously with
the primary lesion. All seven patients were treated by surgical resection
of the lung nodules and chemotherapy. Of the seven patients, four were
alive and free of disease after an average follow-up of nine years; two
were receiving chemotherapy; and one, who had had immunosuppression for an
allograft transplant, died less than one year after the discovery of the
pulmonary lesions. Based on this small series, we concluded that patients
with a Stage-3 giant-cell tumor of bone may be at risk for pulmonary spread
of the disease. This lesion, with its benign histological picture even in
lung lesions, has a favorable prognosis when treated with pulmonary
resection of the nodules. However, the role for chemotherapy after
pulmonary surgery is still unclear.
 CiteULike  Connotea  Del.icio.us  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Matsuo, E. Hiyama, T. Sugita, S. Shimose, T. Kubo, Y. Mochizuki, N. Adachi, K. Kojima, P. Sharman, and M. Ochi
Telomerase Activity in Giant Cell Tumors of Bone
Ann. Surg. Oncol.,
October 1, 2007;
14(10):
2896 - 2902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Hoch, C. Inwards, M. Sundaram, and A. E. Rosenberg
Multicentric Giant Cell Tumor of Bone. Clinicopathologic Analysis of Thirty Cases
J. Bone Joint Surg. Am.,
September 1, 2006;
88(9):
1998 - 2008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. V. von Steyern, H. C. F. Bauer, C. Trovik, A. Kivioja, P. Bergh, P. H. Jorgensen, G. Folleras, and A. Rydholm
Treatment of local recurrences of giant cell tumour in long bones after curettage and cementing: A SCANDINAVIAN SARCOMA GROUP STUDY
J Bone Joint Surg Br,
April 1, 2006;
88-B(4):
531 - 535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Gamberi, M. S. Benassi, P. Ragazzini, L. Pazzaglia, F. Ponticelli, C. Ferrari, A. Balladelli, M. Mercuri, M. Gigli, F. Bertoni, et al.
Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone
Ann. Onc.,
March 1, 2004;
15(3):
498 - 503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Murphey, G. C. Nomikos, D. J. Flemming, F. H. Gannon, H. T. Temple, and M. J. Kransdorf
Imaging of Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone: Radiologic-Pathologic Correlation
RadioGraphics,
September 1, 2001;
21(5):
1283 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. LEWIS, J. H. HEALEY, A. G. HUVOS, and M. BURT
Benign Giant-Cell Tumor of Bone with Metastasis to Mediastinal Lymph Nodes. A Case Report of Resection Facilitated with Use of steroids
J. Bone Joint Surg. Am.,
January 1, 1996;
78(1):
106 - 10.
[Full Text]
|
|
|
|
