|
The Journal of Bone and Joint Surgery, Vol 66, Issue 1 95-106, Copyright © 1984 by Journal of Bone and Joint Surgery, Inc
The composition of normal and osteoarthritic articular cartilage from human knee joints. With special reference to unicompartmental replacement and osteotomy of the knee
R Brocklehurst, MT Bayliss, A Maroudas, HL Coysh, MA Freeman, PA Revell and SY Ali
The articular cartilage from nineteen osteoarthritic and fourteen normal
control adult human knee joints was analyzed for changes in water content,
proteoglycan composition and structure, glycosaminoglycan synthesis rates,
and cell content. We found no significant differences between visually
intact cartilage from osteoarthritic knee joints and cartilage from control
joints for any of the parameters studied. In osteoarthritic specimens in
which the cartilage surface was not intact the biochemical changes depended
on the degree of fibrillation. Surface-fibrillated specimens had a higher
water content in the surface layers but no change in the content or
synthesis rate of glycosaminoglycan. Deeply fibrillated cartilage, however,
had an increased water content through its full depth, and there was a
decrease in both the rate of synthesis and the content of
glycosaminoglycans. Clinical Relevance: The results of this study suggest
that degenerative changes in osteoarthritic knees are focal in origin and
that corrective osteotomy or unicompartmental joint replacement might be
rational procedures for knees in which the cartilage in all of one
compartment is visually intact.
 CiteULike  Connotea  Del.icio.us  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. K. Amin, J. S. Huntley, P. G. Bush, A. H. R.W. Simpson, and A. C. Hall
Osmolarity Influences Chondrocyte Death in Wounded Articular Cartilage
J. Bone Joint Surg. Am.,
July 1, 2008;
90(7):
1531 - 1542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Burton-Wurster, R. G. Mateescu, R. J. Todhunter, K. M. Clements, Q. Sun, V. Scarpino, and G. Lust
Genes in Canine Articular Cartilage That Respond to Mechanical Injury: Gene Expression Studies With Affymetrix Canine GeneChip
J. Hered.,
November 1, 2005;
96(7):
821 - 828.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.S. Huntley, P.G. Bush, J.M. McBirnie, A.H. Simpson, and A.C. Hall
Chondrocyte Death Associated with Human Femoral Osteochondral Harvest as Performed for Mosaicplasty
J. Bone Joint Surg. Am.,
February 1, 2005;
87(2):
351 - 360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Bobacz, L Erlacher, J Smolen, A Soleiman, and W B Graninger
Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage
Ann Rheum Dis,
December 1, 2004;
63(12):
1618 - 1622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Hickery, M. T. Bayliss, J. Dudhia, J. C. Lewthwaite, J. C. W. Edwards, and A. A. Pitsillides
Age-related Changes in the Response of Human Articular Cartilage to IL-1{alpha} and Transforming Growth Factor-{beta} (TGF-{beta}): CHONDROCYTES EXHIBIT A DIMINISHED SENSITIVITY TO TGF-{beta}
J. Biol. Chem.,
December 26, 2003;
278(52):
53063 - 53071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Iorio and W. L. Healy
Unicompartmental Arthritis of the Knee
J. Bone Joint Surg. Am.,
July 3, 2003;
85(7):
1351 - 1364.
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Duvvuri, S. R. Charagundla, S. B. Kudchodkar, J. H. Kaufman, J. B. Kneeland, R. Rizi, J. S. Leigh, and R. Reddy
Human Knee: In Vivo T1{rho}-weighted MR Imaging at 1.5 T—Preliminary Experience
Radiology,
September 1, 2001;
220(3):
822 - 826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. R. Noyes, S. D. Barber, and R. Simon
High tibial osteotomy and ligament reconstruction in varus angulated, anterior cruciate ligament-deficient knees: A two- to seven-year follow-up study
Am. J. Sports Med.,
January 1, 1993;
21(1):
2 - 12.
[Abstract]
[PDF]
|
|
|
|
