The Journal of Bone and Joint Surgery, Vol 65, Issue 3 381-389, Copyright © 1983 by Journal of Bone and Joint Surgery, Inc
Leakage of radioactive particle systems from a synovial joint studied with a gamma camera. Its application to radiation synovectomy
J Noble, AG Jones, MA Davies, CB Sledge, RI Kramer and E Livni
We have determined rates of leakage of radioactivity from a rabbit synovial
pouch in vivo for a number of particle systems of varying sizes and
differing resistance to degradation. The estimates were made using a gamma
scintillation camera and without killing the test animals. The lowest
leakage at twenty-four hours was seen with inert carbonized microspheres
and the highest rates were seen with surface-labeled particles of
biodegradable denatured human serum albumin and with erythrocytes. The
carbonized microspheres had no adverse long-term effects on the health of
the animals' articular cartilage. Clinical Relevance: Results obtained with
inert particles indicate that reducing the biodegradability of the particle
or increasing its diameter, or both, reduces radioactivity losses from the
knee joint. Large (twenty-five-micrometer-diameter) microspheres of human
serum albumin incorporating the radioactivity and carbonized microspheres
are suggested as potential carriers of isotopes for human radiation
synovectomy.
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