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The Journal of Bone and Joint Surgery, Vol 64, Issue 1 88-94, Copyright © 1982 by Journal of Bone and Joint Surgery, Inc
Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content
CG Armstrong and VC Mow
In a series of 103 specimens from the lateral facet of the human patella,
the intrinsic mechanical properties of articular cartilage were measured
using a confined compression creep test. By considering the cartilage as a
porous, permeable solid filed with fluid, this experimental procedure
allowed the determination of the intrinsic equilibrium modulus of the
cartilage matrix and its permeability to fluid flow. The intrinsic
equilibrium modulus and the permeability both were highly correlated with
the water content of the tissue; as water content increased, the matrix of
the tissue became softer and more permeable. There was only a marginal
decrease in the equilibrium modulus of the tissue with increasing age and
surface degeneration. The permeability of the cartilage matrix was not
significantly correlated with age or degeneration. Clinical Relevance: We
concluded that the visual or histological appearance of a cartilage
specimen may be a poor indicator of its ability to function as the bearing
material in the intact joint. A more reliable indicator of the functional
properties of a specimen can be obtained either by direct mechanical
testing or by biochemical analysis of its composition.
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