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The Journal of Bone and Joint Surgery, Vol 64, Issue 1 63-66, Copyright © 1982 by Journal of Bone and Joint Surgery, Inc
High and low-dose aspirin prophylaxis against venous thromboembolic disease in total hip replacement
WH Harris, CA Athanasoulis, AC Waltman and EW Salzman
Aspirin has been demonstrated to be an effective prophylactic agent against
postoperative venous thromboembolic disease, but the optimum dosage is
unknown. We compared the efficacy of daily doses of 3.6 grams of aspirin
(high dose) with that of 1.2 grams (low dose) in 182 patients. All patients
were more than forty years old and all underwent a total hip replacement.
This randomized, prospective, double-blind study was done using only
objective dta for diagnosis. Twenty-three (44 per cent) of fifty-two women
who were treated with the low dose had thrombi, compared with eighteen (34
per cent) of fifty-three women who were given the high dose. Thrombi
developed in thirteen (32 per cent) and in eighteen (49 per cent) of
thirty-seven men who were given the high dose. There were no statistically
significant differences among the four groups, nor was there a significant
difference among the subgroups that were determined according to prior
history of venous thromboembolic disease. Therefore, the higher dose of
aspirin was neither more nor less effective than the lower dose. Our data
continue to support the use of 1.2 grams in men.
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