|
The Journal of Bone and Joint Surgery, Vol 64, Issue 1 63-66, Copyright © 1982 by Journal of Bone and Joint Surgery, Inc
High and low-dose aspirin prophylaxis against venous thromboembolic disease in total hip replacement
WH Harris, CA Athanasoulis, AC Waltman and EW Salzman
Aspirin has been demonstrated to be an effective prophylactic agent against
postoperative venous thromboembolic disease, but the optimum dosage is
unknown. We compared the efficacy of daily doses of 3.6 grams of aspirin
(high dose) with that of 1.2 grams (low dose) in 182 patients. All patients
were more than forty years old and all underwent a total hip replacement.
This randomized, prospective, double-blind study was done using only
objective dta for diagnosis. Twenty-three (44 per cent) of fifty-two women
who were treated with the low dose had thrombi, compared with eighteen (34
per cent) of fifty-three women who were given the high dose. Thrombi
developed in thirteen (32 per cent) and in eighteen (49 per cent) of
thirty-seven men who were given the high dose. There were no statistically
significant differences among the four groups, nor was there a significant
difference among the subgroups that were determined according to prior
history of venous thromboembolic disease. Therefore, the higher dose of
aspirin was neither more nor less effective than the lower dose. Our data
continue to support the use of 1.2 grams in men.
 CiteULike  Connotea  Del.icio.us  Facebook  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Patrono, C. Baigent, J. Hirsh, and G. Roth
Antiplatelet Drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Chest,
June 1, 2008;
133(6_suppl):
199S - 233S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Patrono and B. Rocca
Aspirin: Promise and Resistance in the New Millennium
Arterioscler Thromb Vasc Biol,
March 1, 2008;
28(3):
s25 - s32.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Berger, A. Stebbins, C. B. Granger, E. M. Ohman, P. W. Armstrong, F. Van de Werf, H. D. White, R. J. Simes, R. A. Harrington, R. M. Califf, et al.
Initial Aspirin Dose and Outcome Among ST-Elevation Myocardial Infarction Patients Treated With Fibrinolytic Therapy
Circulation,
January 15, 2008;
117(2):
192 - 199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Patrono, B. Coller, G. A. FitzGerald, J. Hirsh, and G. Roth
Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
Chest,
September 1, 2004;
126(3_suppl):
234S - 264S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Patrono, B. Coller, J. E. Dalen, G. A. FitzGerald, V. Fuster, M. Gent, J. Hirsh, and G. Roth
Platelet-Active Drugs : The Relationships Among Dose, Effectiveness, and Side Effects
Chest,
January 1, 2001;
119
(2009):
39S - 63S.
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. H. Geerts, J. A. Heit, G. P. Clagett, G. F. Pineo, C. W. Colwell, F. A. Anderson Jr., and H. B. Wheeler
Prevention of Venous Thromboembolism
Chest,
January 1, 2001;
119
(2009):
132S - 175S.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. B. Freedman, K. R. Brookenthal, R. H. Fitzgerald, S. Williams, and J. H. Lonner
A Meta-Analysis of Thromboembolic Prophylaxis Following Elective Total Hip Arthroplasty
J. Bone Joint Surg. Am.,
July 1, 2000;
82(7):
929 - 929.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. H. WESTRICH and T. P. SCULCO
Prophylaxis against Deep Venous Thrombosis after Total Knee Arthroplasty. Pneumatic Plantar Compression and Aspirin Compared with Aspirin Alone
J. Bone Joint Surg. Am.,
June 1, 1996;
78(6):
826 - 34.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. F. Imperiale and T. Speroff
A Meta-analysis of Methods to Prevent Venous Thromboembolism Following Total Hip Replacement
JAMA,
June 8, 1994;
271(22):
1780 - 1785.
[Abstract]
[PDF]
|
|
|
|
