|
The Journal of Bone and Joint Surgery, Vol 62, Issue 1 79-89, Copyright © 1980 by Journal of Bone and Joint Surgery, Inc
Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee
T Furukawa, DR Eyre, S Koide and MJ Glimcher
Wounds penetrating articular cartilage to bone heal with cartilage
described variably as either fibrous or hyaline. In the present study, such
repair cartilage was induced in the rabbit for biochemical comparison with
normal articular cartilage. The main collagen in the repair tissue after
three weeks was type I. By six to eight weeks, type II had become
predominant and continued to be enriched up to one year; but type I still
persisted as a significant constituent of the repair tissue even after a
year, so the repair cartilage never fully resembled normal articular
cartilage. From radiochemical analysis, type II was determined to be the
major collagen synthesized by the repair tissue after three to four weeks.
After six months, the repair cartilage contained more collagen and less
hexosamine than control cartilage, suggesting that the fibrous texture that
often developed was due to a loss of proteoglycans rather than to a change
in the type of collagen. Clinical Relevance: Procedures capable of inducing
the differentiation of authentic articular cartilage to resurface
degenerated human joints would be invaluable. Surgical methods, such as
drilling through to subchondral bone, are often attempted. It is not known,
however, whether the cartilage that forms is true articular cartilage or,
for example, fibrocartilage. The present experimental study in rabbits
compared the properties of such repair cartilage with those of normal
articular cartilage.
 CiteULike  Connotea  Del.icio.us  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. B.L. Lee, J. H.P. Hui, I. C. Song, L. Ardany, and E. H. Lee
Injectable Mesenchymal Stem Cell Therapy for Large Cartilage Defects A Porcine Model
Stem Cells,
November 1, 2007;
25(11):
2964 - 2971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Voloshin, K. R. Morse, C. D. Allred, S. A. Bissell, M. D. Maloney, and K. E. DeHaven
Arthroscopic Evaluation of Radiofrequency Chondroplasty of the Knee
Am. J. Sports Med.,
October 1, 2007;
35(10):
1702 - 1707.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. C. Kreuz, M. Steinwachs, C. Erggelet, A. Lahm, S. Krause, C. Ossendorf, D. Meier, N. Ghanem, and M. Uhl
Importance of Sports in Cartilage Regeneration After Autologous Chondrocyte Implantation: A Prospective Study With a 3-Year Follow-up
Am. J. Sports Med.,
August 1, 2007;
35(8):
1261 - 1268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Watanabe, Y. Wada, T. Obata, T. Ueda, M. Tamura, H. Ikehira, and H. Moriya
Delayed Gadolinium-enhanced MR to Determine Glycosaminoglycan Concentration in Reparative Cartilage after Autologous Chondrocyte Implantation: Preliminary Results
Radiology,
April 1, 2006;
239(1):
201 - 208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Y. C. Huang, P. M. Reuben, and H. S. Cheung
Temporal Expression Patterns and Corresponding Protein Inductions of Early Responsive Genes in Rabbit Bone Marrow-Derived Mesenchymal Stem Cells Under Cyclic Compressive Loading
Stem Cells,
September 1, 2005;
23(8):
1113 - 1121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yanai, T. Ishii, F. Chang, and N. Ochiai
Repair of large full-thickness articular cartilage defects in the rabbit: THE EFFECTS OF JOINT DISTRACTION AND AUTOLOGOUS BONE-MARROW-DERIVED MESENCHYMAL CELL TRANSPLANTATION
J Bone Joint Surg Br,
May 1, 2005;
87-B(5):
721 - 729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Gill, P. C. McCulloch, S. S. Glasson, T. Blanchet, and E. A. Morris
Chondral Defect Repair After the Microfracture Procedure: A Nonhuman Primate Model
Am. J. Sports Med.,
May 1, 2005;
33(5):
680 - 685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Alford and B. J. Cole
Cartilage Restoration, Part 1: Basic Science, Historical Perspective, Patient Evaluation, and Treatment Options
Am. J. Sports Med.,
February 1, 2005;
33(2):
295 - 306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Katayama, S. Wakitani, N. Tsumaki, Y. Morita, I. Matsushita, R. Gejo, and T. Kimura
Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow
Rheumatology,
August 1, 2004;
43(8):
980 - 985.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C-Y C. Huang, K. L. Hagar, L. E. Frost, Y. Sun, and H. S. Cheung
Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone-Marrow Derived Mesenchymal Stem Cells
Stem Cells,
May 1, 2004;
22(3):
313 - 323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Grande, J. Mason, E. Light, and D. Dines
Stem Cells as Platforms for Delivery of Genes to Enhance Cartilage Repair
J. Bone Joint Surg. Am.,
April 28, 2003;
85(90002):
111 - 116.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H.-S. Lee, G.-T. Huang, H. Chiang, L.-L. Chiou, M.-H. Chen, C.-H. Hsieh, and C.-C. Jiang
Multipotential Mesenchymal Stem Cells from Femoral Bone Marrow Near the Site of Osteonecrosis
Stem Cells,
March 1, 2003;
21(2):
190 - 199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Ahmad, Z. A. Cohen, W. N. Levine, G. A. Ateshian, and V. C. Mow
Biomechanical and Topographic Considerations for Autologous Osteochondral Grafting in the Knee
Am. J. Sports Med.,
March 1, 2001;
29(2):
201 - 206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. SELLERS, R. ZHANG, S. S. GLASSON, H. D. KIM, D. PELUSO, D. A. D'AUGUSTA, K. BECKWITH, and E. A. MORRIS
Repair of Articular Cartilage Defects One Year After Treatment with Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)
J. Bone Joint Surg. Am.,
February 1, 2000;
82(2):
151 - 60.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. I. Caplan and J. E. Dennis
Genetically Linked Scientists: The One-Two Punch For NFATp Knockout
J. Exp. Med.,
January 3, 2000;
191(1):
1 - 4.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. O'DRISCOLL
Current Concepts Review - The Healing and Regeneration of Articular Cartilage
J. Bone Joint Surg. Am.,
December 1, 1998;
80(12):
1795 - 1812.
[Full Text]
|
|
|
|
|
|
|
B. R. Mandelbaum, J. E. Browne, F. Fu, L. Micheli, J. B. Mosely Jr, C. Erggelet, T. Minas, and L. Peterson
Articular Cartilage Lesions of the Knee
Am. J. Sports Med.,
November 1, 1998;
26(6):
853 - 861.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. SELLERS, D. PELUSO, and E. A. MORRIS
The Effect of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) on the Healing of Full-Thickness Defects of Articular Cartilage
J. Bone Joint Surg. Am.,
October 1, 1997;
79(10):
1452 - 63.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. JÜRGENSEN, D. AESCHLIMANN, V. CAVIN, M. GENGE, and E. B. HUNZIKER
A New Biological Glue for Cartilage-Cartilage Interfaces: Tissue Transglutaminase
J. Bone Joint Surg. Am.,
February 1, 1997;
79(2):
185 - 93.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. B. TRIPPEL, R. D. COUTTS, T. A. EINHORN, G. R. MUNDY, and R. G. ROSENFELD
Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Growth Factors as Therapeutic Agents*{{dagger}}
J. Bone Joint Surg. Am.,
August 1, 1996;
78(8):
1272 - 86.
[Full Text]
|
|
|
|
|
|
|
M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson
Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation
N. Engl. J. Med.,
October 6, 1994;
331(14):
889 - 895.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. A. Paletta, S. P. Arnoczky, and R. F. Warren
The repair of osteochondral defects using an exogenous fibrin clot: An experimental study in dogs
Am. J. Sports Med.,
December 1, 1992;
20(6):
725 - 731.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Wojtys, M. Wilson, K. Buckwalter, E. Braunstein, and W. Martel
Magnetic resonance imaging of knee hyaline cartilage and intraarticular pathology
Am. J. Sports Med.,
September 1, 1987;
15(5):
455 - 463.
[Abstract]
[PDF]
|
|
|
|
