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The Journal of Bone and Joint Surgery, Vol 61, Issue 8 1203-1207, Copyright © 1979 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Methylmethacrylate is a mutagen for Salmonella typhimurium

R Poss, WG Thilly and DA Kaden

The long-term effects of exposure to monomeric methylmethacrylate have yet to be established. We have measured the toxicity and mutagenicity of methylmethacrylate for Salmonella typhimurium. At levels of thirty-four millimolar, methylmethacrylate exhibited 28 per cent of the mutagenic activity of an equimolar dose of dimethylnitrosamine. Methylmethacrylate alone exhibited toxicity to the bacteria, but when the methylmethacrylate was incubated with a rat-liver enzyme metabolizing system, mutagenesis was induced. These findings suggest that an intermediate metabolite of methylmethacrylate is mutagenic to Salmonella typhimurium.
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