The Journal of Bone and Joint Surgery, Vol 61, Issue 1 105-111, Copyright © 1979 by Journal of Bone and Joint Surgery, Inc
Serial serum protein determinations in scoliotic children treated by spine fusion and autotransfusion
RC Parlett and R Naidu
In a longitudinal study, serum protein levels were determined by more than
1200 radial immunodiffusion assays in fifty pediatric scoliotic patients
whose blood replacement during spine fusion was provided by predeposition
autotransfusion. Several serial samples of serum were obtained at intervals
from the time of admission through surgery and discharge and they were
examined for eight serum proteins: IgG, IgA, IgM, albumin, transferrin, C3c
(B1A globulin), beta-lipoprotein, and alpha2-macroglobulin. The results
indicated that neither the three phlebotomies performed to obtain
predeposition autologuus blood for reinfusion nor the loss of blood during
surgery resulted in significant alteration of any of the serum protein
levels at the sampling times tested. The greatest decreases in the serum
concentrations of all eight proteins were observed during the early
postoperative recovery period.