This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheung, H. S.
Right arrow Articles by Nimni, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheung, H. S.
Right arrow Articles by Nimni, M. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?

The Journal of Bone and Joint Surgery, Vol 60, Issue 8 1076-1081, Copyright © 1978 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

In vitro collagen biosynthesis in healing and normal rabbit articular cartilage

HS Cheung, WH Cottrell, K Stephenson and ME Nimni

To examine the repair collagens produced by cells in injured cartilage, the femoral articular surfaces of three groups of New Zealand white rabbits were injured by making both superficial and deep lacerations and drill holes. Eight weeks after surgery, the rabbits were killed and slices of injured articular cartilage were harvested. The types of collagen being synthesized at the site of these lesions were identified by labeling the recovered specimens in vitro with 3H-proline and by characterizing the collagen using sodium dodecyl sulphate electrophoresis, carboxymethyl cellulose chromatography, and cyanogen bromide peptide analysis. In all cases, tissue-specific type II ([alpha1 (II)]3) cartilage collagen was synthesized. Histological examination using toluidine blue showed that the chondrocytes bordering the cartilage defect produced by deep lacerations and drill holes responded by increased cellular activity, as shown by cell cloning and increased matrix staining. The drilled holes were completely filled by tissue with staining and morphological characteristics similar to those of hyaline cartilage.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Stem CellsHome page
C.-Y. C. Huang, P. M. Reuben, and H. S. Cheung
Temporal Expression Patterns and Corresponding Protein Inductions of Early Responsive Genes in Rabbit Bone Marrow-Derived Mesenchymal Stem Cells Under Cyclic Compressive Loading
Stem Cells, September 1, 2005; 23(8): 1113 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
C-Y C. Huang, K. L. Hagar, L. E. Frost, Y. Sun, and H. S. Cheung
Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone-Marrow Derived Mesenchymal Stem Cells
Stem Cells, May 1, 2004; 22(3): 313 - 323.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
R. S. NAMBA, M. MEULI, K. M. SULLIVAN, A. X. LE, and N. S. ADZICK
Spontaneous Repair of Superficial Defects in Articular Cartilage in a Fetal Lamb Model
J. Bone Joint Surg. Am., January 1, 1998; 80(1): 4 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Am J Sports MedHome page
G. A. Paletta, S. P. Arnoczky, and R. F. Warren
The repair of osteochondral defects using an exogenous fibrin clot: An experimental study in dogs
Am. J. Sports Med., December 1, 1992; 20(6): 725 - 731.
[Abstract] [PDF]

Home page
 Am J Sports MedHome page
E. Wojtys, M. Wilson, K. Buckwalter, E. Braunstein, and W. Martel
Magnetic resonance imaging of knee hyaline cartilage and intraarticular pathology
Am. J. Sports Med., September 1, 1987; 15(5): 455 - 463.
[Abstract] [PDF]