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The Journal of Bone and Joint Surgery, Vol 60, Issue 3 359-362, Copyright © 1978 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Cefazolin concentrations in bone and synovial fluid

DJ Schurman, HP Hirshman, G Kajiyama, K Moser and DS Burton

A single intravenous dose of one gram of cefazolin was administered prophylactically to forty-eight patients undergoing total joint replacement. The serum half-life of the antibiotic was 1.8 hours, the same value found in normal volunteers. The mean concentration in bone during surgery was 5.7 micrograms per gram of bone. The mean concentration in synovial fluid during surgery was 24.4 micrograms per milliliter of fluid.
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M. J. J. METER, M. D. W. POLLY JR., L. C. R. P. BRUECKNER, M. J. J. TENUTA, L. ASPLUND, and W. J. HOPKINSON
Effect of Intraoperative Blood Loss on the Serum Level of Cefazolin in Patients Managed with Total Hip Arthroplasty. A Prospective, Controlled Study
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