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The Journal of Bone and Joint Surgery, Vol 60, Issue 3 355-358, Copyright © 1978 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Methylmethacrylate: A study of teratogenicity and fetal toxocity of the vapor in the mouse

RE McLaughlin, SI Reger, JA Barkalow, MS Allen and CA Dafazio

To determine possible deleterious effects of methylmethacrylate vapor on mouse gestation, pregnant mice were exposed to average vapor concentrations of 1330 parts per million for two hours twice daily during Day 6 through Day 15 of pregnancy. A slight increase in the average weight of the fetuses of the exposed mothers were demonstrated but no other evidence of fetal toxicity or teratologic effects was found. During three total hip replacements, the concentration of methylmethacrylate in operating-room air never rose above 280 parts per million.
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