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The Journal of Bone and Joint Surgery, Vol 60, Issue 1 93-96, Copyright © 1978 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Concentration of antibiotics in normal bone after intravenous injection

CE Wiggins, CL Nelson, R Clarke and CH Thompson

The concentrations in serum, cancellous bone, and cortical bone of three antibiotics--nafcillin, cefazolin, and gentamicin--were measured in eleven normal dogs. All antibiotics rapidly penetrated into bone. The peak concentration in serum was reached within twenty minutes of intravenous injections, and the concentration in bone generally paralleled that in serum. Cancellous bone had higher concentrations than did cortical bone because of the admixture of blood.
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