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The Journal of Bone and Joint Surgery, Vol 59, Issue 8 1052-1060, Copyright © 1977 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Multicentric giant-cell tumor of bone

FH Sim, DC Dahlin and JW Beabout

The presence of more than one distinct giant-cell tumor in the same patient is rare; seven cases have been reported in the literature. The present series involves eleven patients with thirty-five individual tumors. Multifocal giant-cell tumors may pose a diagnostic problem. It is difficult to distinguish a multicentric giant-cell tumor from a primary giant-cell tumor with metastatic spread. This problem is magnified when the second lesion is not noted at the onset or is metaphyseal in location. Moreover, these lesions present a therapeutic challenge to the surgeon. Multiple lesions tend to exhibit the same aggressive clinical behavior as a solitary giant-cell tumor. A high recurrence rate after curettage indicates that aggressive surgical management is necessary.
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