|
The Journal of Bone and Joint Surgery, Vol 59, Issue 6 729-735, Copyright © 1977 by Journal of Bone and Joint Surgery, Inc
Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits
GJ Wang, DE Sweet, SI Reger and RC Thompson
Large doses of cortisone were given to growing and adult rabbits over a
five-month period to produce avascular necrosis of the femoral head. The
cortisone caused an increase in the serum cholesterol, fatty metamorphosis
of the liver, and fat emboli visible in sections of the femur and humerus.
These emboli partially obliterated the microcirculation of the subchondral
vessels of both femoral and humeral heads. The average diameter of the
marrow fat cells also increased more than ten micrometers. This increase in
cell volume might be significant because in the closed chamber of the
femoral head it could increase tissue pressure, diminish perfusion, and be
the mechanism for avascular necrosis induced by cortisone.
 CiteULike  Connotea  Del.icio.us  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
N. Di Iorgi, M. Rosol, S. D. Mittelman, and V. Gilsanz
Reciprocal Relation between Marrow Adiposity and the Amount of Bone in the Axial and Appendicular Skeleton of Young Adults
J. Clin. Endocrinol. Metab.,
June 1, 2008;
93(6):
2281 - 2286.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. David, A. Martin, M.-H. Lafage-Proust, L. Malaval, S. Peyroche, D. B. Jones, L. Vico, and A. Guignandon
Mechanical Loading Down-Regulates Peroxisome Proliferator-Activated Receptor {gamma} in Bone Marrow Stromal Cells and Favors Osteoblastogenesis at the Expense of Adipogenesis
Endocrinology,
May 1, 2007;
148(5):
2553 - 2562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Niinimaki, A. H. Harila-Saari, A. E. Jartti, R. M. Seuri, P. V. Riikonen, E. L. Paakko, M. I. Mottonen, and M. Lanning
High Body Mass Index Increases the Risk for Osteonecrosis in Children With Acute Lymphoblastic Leukemia
J. Clin. Oncol.,
April 20, 2007;
25(12):
1498 - 1504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Cui, Y. Wang, K. J. Saleh, G.-J. Wang, and G. Balian
Alcohol-Induced Adipogenesis in a Cloned Bone-Marrow Stem Cell
J. Bone Joint Surg. Am.,
November 1, 2006;
88(suppl_3):
148 - 154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kabata, T. Kubo, T. Matsumoto, T. Hirata, M. Fujioka, K. A. Takahashi, S. Yagishita, M. Kobayashi, and K. Tomita
Onset of steroid-induced osteonecrosis in rabbits and its relationship to hyperlipaemia and increased free fatty acids
Rheumatology,
October 1, 2005;
44(10):
1233 - 1237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ichiseki, A. Kaneuji, S. Katsuda, Y. Ueda, T. Sugimori, and T. Matsumoto
DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis
Rheumatology,
April 1, 2005;
44(4):
456 - 460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Schellinger, C. S. Lin, J. Lim, H. G. Hatipoglu, J. C. Pezzullo, and A. J. Singer
Bone Marrow Fat and Bone Mineral Density on Proton MR Spectroscopy and Dual-Energy X-Ray Absorptiometry: Their Ratio as a New Indicator of Bone Weakening
Am. J. Roentgenol.,
December 1, 2004;
183(6):
1761 - 1765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Gangji, J.-P. Hauzeur, C. Matos, V. De Maertelaer, M. Toungouz, and M. Lambermont
Treatment of Osteonecrosis of the Femoral Head with Implantation of Autologous Bone-Marrow Cells. A Pilot Study
J. Bone Joint Surg. Am.,
June 1, 2004;
86(6):
1153 - 1160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Boss and I. Misselevich
Osteonecrosis of the Femoral Head of Laboratory Animals: The Lessons Learned from a Comparative Study of Osteonecrosis in Man and Experimental Animals
Vet. Pathol.,
July 1, 2003;
40(4):
345 - 354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Lieberman, D. J. Berry, M. A. Montv, R. K. Aaron, J. J. Callaghan, A. Rayadhyaksha, and J. R. Urbaniak
Osteonecrosis of the Hip: Management in the Twenty-first Century
J. Bone Joint Surg. Am.,
May 1, 2002;
84(5):
834 - 853.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Oinuma, Y Harada, Y Nawata, K Takabayashi, I Abe, K Kamikawa, and H Moriya
Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment
Ann Rheum Dis,
December 1, 2001;
60(12):
1145 - 1148.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Mattano Jr, H. N. Sather, M. E. Trigg, and J. B. Nachman
Osteonecrosis as a Complication of Treating Acute Lymphoblastic Leukemia in Children: A Report From the Children's Cancer Group
J. Clin. Oncol.,
September 18, 2000;
18(18):
3262 - 3272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. CUI, G.-J. WANG, and G. BALIAN
Steroid-Induced Adipogenesis in a Pluripotential Cell Line from Bone Marrow
J. Bone Joint Surg. Am.,
July 1, 1997;
79(7):
1054 - 63.
[Abstract]
[Full Text]
|
|
|
|
