The Journal of Bone and Joint Surgery, Vol 59, Issue 3 386-390, Copyright © 1977 by Journal of Bone and Joint Surgery, Inc
Experimental sensory reinnervation of the median nerve by nerve transfer in monkeys
PB Chacha, A Krishnamurti and K Soin
Anastomosis of the superficial radial nerve, the dorsal cutaneous branch of
the ulnar nerve, or both to the distal cut end of a widely resected median
nerve in monkeys was followed by successful sensory reinnervation of the
thumb, index finger, and long finger within thiry-five to forty weeks.
Success was ascertained by the presence of an intact anastomosis as
observed grossly without any evidence of spontaneous regeneration of the
median nerve. Reinnervation was confirmed by histological and histochemical
reactions observed in the Meissner's corpuscles in the skin innervated by
the median nerve. The demonstration of nerve fiber and the presence of
normal specific and non-specific cholinesterase reactions exhibited by the
Meissner's corpuscles in the cholinesterase preparations were considered
the histological criteria for successful reinnervation. These histological
and histochemical observations may explain the reported functional sensory
recovery in clinical cases when similar nerve transfers were done.
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