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The Journal of Bone and Joint Surgery, Vol 58, Issue 8 1153-1156, Copyright © 1976 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Fracture healing in the presence of chronic hypoxia

RB Heppenstall, CW Goodwin and CT Brighton

Recent studies have demonstrated that fracture healing normally takes place under hypoxic conditions. The present study evaluated the effect of a state of chronic systemic hypoxia on fracture healing in dogs. A significant delay in fracture healing was demonstrated in the hypoxic animals roentgenographically, histologically, and by strength-testing criteria. A further reduction in the available oxygen supply below that present during normal repair had an adverse effect on fracture healing.
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