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The Journal of Bone and Joint Surgery, Vol 58, Issue 3 312-317, Copyright © 1976 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Immunological studies in murine osteosarcoma. Immunogenicity, growth kinetics, and immunotherapy

CW Miller, RF DeBlasi and SJ Fisher

A transplantable murine osteosarcoma is described. Following transplantation into a syngeneic mouse the tumor grows rapidly and kills the mouse with pulmonary metastases simulating human osteosarcoma. A cell-mediated antibody response is evoked in the host mouse as demonstrated by in vivo and in vitro tests. The number of pulmonary metastases may be decreased with adjunctive immunotherapy following excision of the primary tumor. Immunotherapeutic materials include BCG and isologous cells treated with Vibrio cholerae neuraminidase.
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