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The Journal of Bone and Joint Surgery, Vol 57, Issue 2 262-264, Copyright © 1975 by Journal of Bone and Joint Surgery, Inc

JOURNAL CONTENTS

Autosomal dominant inheritance of tibial meromelia. Report of a kindred

MW Clark

Three generations of a family demonstrated an autosomal dominant transmission of congenital absence of the tibia. Nine family members were affected, six in the first generation. Male-to-male, male-to-female, and female-to-female transmission occurred. This is the fourteenth case reported to document familial occurrence of tibial meromelia, and the first to document this mode of inheritance.
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