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Journal of Bone and Joint Surgery, 1974;56:1520-1524.
© 1974 by The Journal of Bone and Joint Surgery, Inc

Candida Pyarthrosis

REPORT OF A CASE AND RESULTS OF TREATMENT WITH 5-FLUOROCYTOSINE

JAMES UMBER M.D.1, MICHAEL W. CHAPMAN M.D.1, and DAVID J. DRUTZ M.D.1

1 Department of Orthopaedic Surgery, San Francisco Medical Center, University of California, San Francisco, California 94143

A case of Candida infection of the knee successfully treated with 5-fluorocytosine is reported. 5-fluorocytosine is a new oral antifungal agent with minimum side effects as compared with amphotericin B, which is currently the drug of choice for severe fungal infections.

Although simple and safe to administer, the use of 5-fluorocytosine requires expert laboratory support with a capability for 5-fluorocytosine assay, broth dilution procedures, and valid species identification.

The pharmacology and clinical application of 5-fluorocytosine are discussed in detail.


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