This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by EHRLICH, M. G.
Right arrow Articles by JONES, H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by EHRLICH, M. G.
Right arrow Articles by JONES, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
Journal of Bone and Joint Surgery, 1974;56:1239-1245.
© 1974 by The Journal of Bone and Joint Surgery, Inc

Uridine Diphosphate (UDP) Stimulation of Protein Polysaccharide Production

A PRELIMINARY REPORT

MICHAEL G. EHRLICH M.D.1, HENRY J. MANKIN M.D.1, BENJAMIN V. TREADWELL B.A.1, and HARDIN JONES B.A.1

1 From the Departments of Orthopaedics of the Massachusetts General Hospital and Harvard Medical School, Boston, and the Hospital for Joint Diseases and Mount Sinai School of Medicine of the City University of New York

Uridine diphosphate, at a concentration of one millimole per milliliter, was found to stimulate the rate of incorporation of 35SO4 and 3H-glycine into articular cartilage both in vivo and in vitro. These findings suggest that uridine diphosphate somehow acts to increase proteoglycan synthesis by the chondrocyte. The mechanism of action is obscure, but the data suggest that uridine diphosphate may act as a stimulator of ribonucleic acid synthesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?