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Journal of Bone and Joint Surgery, 1974;56:1023-1030.
© 1974 by The Journal of Bone and Joint Surgery, Inc

The Response of Non-Traumatized Bone to Direct Current

Z. B. FRIEDENBERG M.D.1, L. M. ZEMSKY M.D.1, and R. P. POLLIS M.D.1

1 From the Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia

A direct constant-current cathode caused bone to form at a site remote from any bone trauma in the medullary cavity of a rabbit tibia. The osteogenic response was current-dependent and the greatest bone respoose developed around cathodes delivering twenty microamperes of current. Excessive current (thirty microamperes or more) caused osteonecrosis. EIevation of voltage also caused bone destruction.


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