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Journal of Bone and Joint Surgery, 1974;56:777-782.
© 1974 by The Journal of Bone and Joint Surgery, Inc

Prophylactic Antibiotics in Clean Orthopaedic Surgery

ALAN PAVEL M.D.1, ROBERT L. SMITH M.D.2, ANTHONY BALLARD 3, and ANDIVAR J. LARSEN M.D.2

1 1441 Kapiolani Boulevard, Honolulu, Hawaii 96814
2 1133 Punchbowl Street, Honolulu, Hawaii 96813
3 Orthopedic Service, Fitzsimons Medical Center, Denver, Colorado 80240

A double-blind prospective study involving 1,591 clean orthopaedic surgical procedures was performed to test the effectiveness of preoperative and intraoperative antibiotics in reducing the postoperative infection rate. The antibiotic and placebo groups were analyzed for factors known to predispose to infection. A decrease in the over-all postoperative infection rate from 5 per cent in the placebo group to 2.8 per cent in the antibiotic group was found.


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