Journal of Bone and Joint Surgery, 1974;56:532-541.
© 1974 by The Journal of Bone and Joint Surgery, Inc
The Role of Antibiotics in the Management of Open Fractures
MICHAEL J. PATZAKIS M.D.1,
J. PAUL HARVEY JR. M.D.1, and
DANIEL IVLER PH.D.1
1 From the Department of Surgery-Orthopedics and the Department of Microbiology, University of Southern California School of Medicine and Los Angeles County General Hospital, Los Angeles
In 310 patients, divided into groups receiving penicillin and streptomycin, cephalothin, or no antibiotics, culture specimens were taken at four stages of triage, and each patient was followed and observed for infection. A correlation was made between retrieval of bacteria after injury and incidence of infection. In control patients the incidence of infection was 13.9 per cent while in the group receiving penicillin and streptomycin it was 9.7 per cent, the difference not being statistically significant. The group of patients receiving cephalothin had a significantly lower infection rate of 2.3 per cent.
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