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Journal of Bone and Joint Surgery, 1974;56:305-310.
© 1974 by The Journal of Bone and Joint Surgery, Inc

Antibiotic Concentrations in Human Bone

A PRELIMINARY REPORT

MICHAEL C. KOLCZUN M.D.1, CARL L. NELSON M.D.1, MARTIN C. MCHENRY M.D.1, THOMAS L. GAVAN M.D.1, and PATRICIA PINOVICH 1

1 From the Department of Orthopaedic Surgery, Section of Orthopaedic Research, the Department of Infectious Diseases, and the Department of Microbiology, the Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, Cleveland

Fifty patients who underwent total hip arthroplasty were given oxacillin preoperatively and intraoperatively. Simultaneous specimens of bone and serum were obtained during the operation and assayed for oxacillin content. The different doses and modes of administration were compared with respect to antibiotic concentration in bone and in serum. Significant oxacillin bone levels were attainable when oxacillin was appropriately administered.


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