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Journal of Bone and Joint Surgery, 1974;56:285-296.
© 1974 by The Journal of Bone and Joint Surgery, Inc

Fibrosarcomatous Dedifferentiation of Primary and Secondary Chondrosarcoma

REVIEW OF FIVE CASES

JOSEPH M. MIRRA M.D.1 and RALPH C. MARCOVE M.D.2

1 The University of California at Los Angeles, Center for the Health Sciences, Los Angeles, California 90024
2 535 East 70th Street, New York, N.Y. 10021

Five of twenty-seven chondrosarcomas seen at the Hospital for Special Surgery from 1952 to 1972 showed fibrosarcomatous dedifferentiation. One was primary and four were secondary, three in patients with enchondromas and one in a patient with Ollier's disease. The development of purely fibrosarcomatous metastases in less than one year in four of the five patients emphasizes the malignant nature of this change.


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