This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GRITZKA, T. L.
Right arrow Articles by LAVIGNE, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GRITZKA, T. L.
Right arrow Articles by LAVIGNE, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
Journal of Bone and Joint Surgery, 1973;55:1698-1720.
© 1973 by The Journal of Bone and Joint Surgery, Inc

Deterioration of Articular Cartilage Caused by Continuous Compression in a Moving Rabbit Joint

A LIGHT AND ELECTRON MICROSCOPIC STUDY

THOMAS L. GRITZKA M.D.1, LOUIS R. FRY M.D.2, ROY L. CHEESMAN 3, and ANGELA LAVIGNE PH.C.2

1 3025 North Vancouver Avenue, Portland, Oregon 97227
2 Department of Orthopaedics, University of Washington, Seattle, Washington
3 Lloyd Medical Engineering Laboratory, 5463 South Othello Street, Seattle, Washington 98118

Extension springs were placed across the elbow joints of mature but not senescent rabbits in a manner which produced compression but allowed the joint to move. Compression was maintained for from one to thirty-two days. Within the range of compression used, the severity of cartilage damage correlated with the duration rather than the magnitude of the compression. As the arthritic lesion developed, the cartilage matrix underwent fibrillation and eventually was eroded away entirely, while a proliferative response was evoked at the joint margin. The chrondrocytes became pyknotic and then, in the end stages, were compressed into linear masses devoid of internal structure.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
P. J. Fanning, G. Emkey, R. J. Smith, A. J. Grodzinsky, N. Szasz, and S. B. Trippel
Mechanical Regulation of Mitogen-activated Protein Kinase Signaling in Articular Cartilage
J. Biol. Chem., December 19, 2003; 278(51): 50940 - 50948.
[Abstract] [Full Text] [PDF]