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Journal of Bone and Joint Surgery, 1973;55:785-794.
© 1973 by The Journal of Bone and Joint Surgery, Inc

Histochemical, Metabolic and Ultrastructural Studies of the Maturation Zone of the Rachitic Rat Epiphyseal Plate

MICHAEL G. EHRLICH M.D.1, CHARLES WEISS M.D.1, HENRY J. MANKIN M.D.1, BENJAMIN V. TREADWELL B.A.1, and CHARLES SANZONE PH.D.1

1 From the Department of Orthopaedics, Hospital for Joint Diseases and Mount Sinai Hospital, Mount Sinai School of Medicine of the City University of New York, New York

Histochemical, autoradiographic, and electron microscopic studies of the maturation zone in the epiphyseal plate of rachitic rats showed a failure of synthesis of polysaccharide and hence of matrix production, a delay in transport of the synthesized macromolecules without alteration in lysosomal enzyme content, and ultrastructural changes consistent with the observed metabolic abnormalities. It is suggested that the principal defect in the maturation zone of the epiphyseal plate of rachitic rats may be a local deficiency in the high energy phosphate required for metabolic activity.


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